The Winthrop Eagles versus the Louisville Cardinals is a game to catch on the Friday Big South college basketball schedule that features a lot of competitive contests. To see all our picks against the spread, scroll down.

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Big South Picks ATS Today

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Pick: Longwood +6.5 vs. UAB

• Matchup: Longwood Lancers vs. UAB Blazers
• Projected Favorite & Spread: Longwood by 3 points (Bet on BetMGM)
• Spread: UAB -6.5
• Time: 12:30 PM ET
• Date: November 22
• TV Channel: ESPN Networks

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Pick: Presbyterian +6.5 vs. Youngstown State

• Matchup: Presbyterian Blue Hose vs. Youngstown State Penguins
• Projected Favorite & Spread: Youngstown State by 4.2 points (Bet on BetMGM)
• Spread: Youngstown State -6.5
• Time: 3:30 PM ET
• Date: November 22
• TV Channel: ESPN+
• Live Stream: ESPN+

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Pick: Winthrop +16.5 vs. Louisville

• Matchup: Winthrop Eagles at Louisville Cardinals
• Projected Favorite & Spread: Louisville by 14.5 points (Bet on BetMGM)
• Spread: Louisville -16.5
• Time: 7:00 PM ET
• Date: November 22
• TV Channel: ACC Network Extra

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