If you’re looking for the best wager to make among the 16 NFL matchups in Week 3, we’re going with the Saints at -2.5 in terms of the point spreads. Don’t stop there, though — scroll down, because we have lots more suggestions, which you could use in a parlay.

Take advantage of our predictions to make your NFL picks this week. BetMGM has all the information you need to begin betting on the NFL.

Best Week 3 Spread Bets

Jump to Matchup:

CHI-IND | BAL-DAL | HOU-MIN | GB-TEN | LAC-PIT

Pick: Colts -1 vs. Bears

• Matchup: Chicago Bears at Indianapolis Colts
• Projected Winner & Margin: Colts by 2.8 points (Bet on this game at BetMGM)
• Spread: Colts -1
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Cowboys +1 vs. Ravens

• Matchup: Baltimore Ravens at Dallas Cowboys
• Projected Winner & Margin: Ravens by 0.7 points (Bet on this game at BetMGM)
• Spread: Ravens -1
• Time: 4:25 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Vikings +1.5 vs. Texans

• Matchup: Houston Texans at Minnesota Vikings
• Projected Winner & Margin: Vikings by 5.1 points (Bet on this game at BetMGM)
• Spread: Texans -1.5
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Packers +1.5 vs. Titans

• Matchup: Green Bay Packers at Tennessee Titans
• Projected Winner & Margin: Packers by 9.0 points (Bet on this game at BetMGM)
• Spread: Titans -1.5
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Steelers -1.5 vs. Chargers

• Matchup: Los Angeles Chargers at Pittsburgh Steelers
• Projected Winner & Margin: Steelers by 1.9 points (Bet on this game at BetMGM)
• Spread: Steelers -1.5
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM.

Best Week 3 Total Bets

Jump to Matchup:

Under 35.5 – Chargers vs. Steelers

• Matchup: Los Angeles Chargers at Pittsburgh Steelers
• Projected Total: 27.0 points (Bet on this game at BetMGM)
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Over 48.5 – Ravens vs. Cowboys

• Matchup: Baltimore Ravens at Dallas Cowboys
• Projected Total: 52.3 points (Bet on this game at BetMGM)
• Time: 4:25 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 49.5 – Eagles vs. Saints

• Matchup: Philadelphia Eagles at New Orleans Saints
• Projected Total: 56.5 points (Bet on this game at BetMGM)
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 46.5 – Chiefs vs. Falcons

• Matchup: Kansas City Chiefs at Atlanta Falcons
• Projected Total: 42.3 points (Bet on this game at BetMGM)
• Time: 8:20 PM ET
• Date: Sept. 22
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 40 – Panthers vs. Raiders

• Matchup: Carolina Panthers at Las Vegas Raiders
• Projected Total: 41.8 points (Bet on this game at BetMGM)
• Time: 4:05 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Catch every NFL touchdown with NFL RedZone on Fubo.

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