Best Bets for NCAA Basketball Picks Against the Spread for Wednesday, January 22
Published 12:23 am Wednesday, January 22, 2025
The La Salle Explorers versus the Saint Louis Billikens is one of many compelling options on Wednesday in college basketball action — suggested picks against the spread for 10 games are available in this article.
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Today’s NCAA Men’s Basketball Picks ATS
ATS Pick: La Salle +10.5 vs. Saint Louis
- Matchup: La Salle Explorers at Saint Louis Billikens
- Time: 8:00 PM ET
- Date: January 22
- Computer Projection: Saint Louis by 6.6 points (Bet now on BetMGM)
- Spread: Saint Louis (-10.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Florida State -1.5 vs. Cal
- Matchup: Florida State Seminoles at California Golden Bears
- Time: 9:00 PM ET
- Date: January 22
- Computer Projection: Florida State by 4.7 points (Bet now on BetMGM)
- Spread: Florida State (-1.5)
- TV Channel: ACC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: Purdue Fort Wayne +1.5 vs. Oakland
- Matchup: Purdue Fort Wayne Mastodons at Oakland Golden Grizzlies
- Time: 7:00 PM ET
- Date: January 22
- Computer Projection: Purdue Fort Wayne by 1.7 points (Bet now on BetMGM)
- Spread: Oakland (-1.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: San Diego State -13.5 vs. Air Force
- Matchup: San Diego State Aztecs at Air Force Falcons
- Time: 10:00 PM ET
- Date: January 22
- Computer Projection: San Diego State by 16.6 points (Bet now on BetMGM)
- Spread: San Diego State (-13.5)
- TV Channel: CBS Sports Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: UNC Greensboro -9.5 vs. Mercer
- Matchup: Mercer Bears at UNC Greensboro Spartans
- Time: 7:00 PM ET
- Date: January 22
- Computer Projection: UNC Greensboro by 12.6 points (Bet now on BetMGM)
- Spread: UNC Greensboro (-9.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
Bet on this or any men’s college basketball matchup at BetMGM.
ATS Pick: George Washington +1.5 vs. UMass
- Matchup: George Washington Revolutionaries at UMass Minutemen
- Time: 7:00 PM ET
- Date: January 22
- Computer Projection: George Washington by 1.4 points (Bet now on BetMGM)
- Spread: UMass (-1.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: USC +5.5 vs. Nebraska
- Matchup: USC Trojans at Nebraska Cornhuskers
- Time: 9:00 PM ET
- Date: January 22
- Computer Projection: Nebraska by 3.1 points (Bet now on BetMGM)
- Spread: Nebraska (-5.5)
- TV Channel: BTN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: South Carolina Upstate +14.5 vs. High Point
- Matchup: High Point Panthers at South Carolina Upstate Spartans
- Time: 7:00 PM ET
- Date: January 22
- Computer Projection: High Point by 12.3 points (Bet now on BetMGM)
- Spread: High Point (-14.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Indiana +5.5 vs. Northwestern
- Matchup: Indiana Hoosiers at Northwestern Wildcats
- Time: 7:00 PM ET
- Date: January 22
- Computer Projection: Northwestern by 3.4 points (Bet now on BetMGM)
- Spread: Northwestern (-5.5)
- TV Channel: BTN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: TCU +6.5 vs. Kansas
- Matchup: Kansas Jayhawks at TCU Horned Frogs
- Time: 7:00 PM ET
- Date: January 22
- Computer Projection: Kansas by 4.5 points (Bet now on BetMGM)
- Spread: Kansas (-6.5)
- TV Channel: ESPN2
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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